Hematopoietic stem cells have been known to play a vital role in cell regeneration and organ repairing functions of the body. These stem cells not only play a role in liver repair and hepatic regeneration but also help in the regeneration of cardiac, skeletal, muscle and brain tissue. In order to investigate the participation of the hematopoietic stem cells in liver repair and the regeneration of hepatic cells, general causes of liver damage must be discussed.
Causes of Liver Damage
Some of the problems and diseases generally concerned with liver damage are listed below:
- chronic viral hepatitis
- liver cirrhosis (generally due to alcohol abuse)
- hepatitis C virus infection (H.C.V.)
- hepatic fibrosis (generally as a result of an auto-immune disease)
- hepatocellular carcinoma (H.C.C.)
- hepatitis B virus infection (H.B.V.)
- liver fibrosis as a result of drug abuse
- metal poisoning
Numerous other disorders could cause improper function, damage or even failure of the hepatic organ, the point being that the general results of these disorders are always very drastic in nature: the disruption of the acid-base equilibrium and the uncontrolled bleeding in multiple organs including the kidneys and the brain are more than enough to be mentioned.
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